We provide a variety of internationally recognized epilepsy animal model construction services, covering three categories: chemical induction, physical stimulation, and genetic engineering, to facilitate basic research and drug development.
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Model Name |
Induction method |
Applicable animals |
Type of attack |
Application Areas |
Model Features |
|
PTZ Model |
Intraperitoneal/subcutaneous injection of PTZ |
Rats and mice |
Acute/chronic myoclonus, spasticity |
Drug screening, attack mechanism research |
Easy to operate, suitable for initial screening of anti-epileptic drugs; can simulate absence seizures |
|
GHB/GBL Model |
Systemic injection of gamma-hydroxybutyrate or its precursors |
Rat |
Absence seizures (SWDs EEG) |
Mechanism of absence epilepsy and evaluation of drug efficacy |
Highly specific absence model; requires EEG monitoring |
|
KA Model |
Intraventricular or systemic injection of KA |
Rats and mice |
Focal→generalized seizures |
The pathogenesis of temporal lobe epilepsy and the development of more effective targeted therapeutic drugs |
The operation is simple and permanent; the latency period and EEG characteristics are highly similar to those of human temporal lobe epilepsy. |
|
Model Name |
Induction method |
Applicable animals |
Type of attack |
Application Areas |
Model Features |
|
Electric ignition model |
Repetitive electrical stimulation of the hippocampus/amygdala |
Rat |
Focal→generalized seizures |
Drug-resistant epilepsy and neuroplasticity research |
Simulate the progression of epilepsy; requires surgical implantation of electrodes, which takes a long time |
|
6Hz corneal stimulation model |
6Hz current stimulation of the cornea |
Rat |
Psychomotor epilepsy |
Drug resistance screening |
Non-invasive, high success rate; simulates complex partial seizures |
|
MES Model |
Maximum electric shock stimulation |
Mice, rat |
Generalized tonic-clonic seizure |
Gold standard screening for anticonvulsant drugs |
Rapid and standardized; biased towards ion channel drug testing |
|
Gene Targets |
Mutation type |
Applicable animals |
Phenotypic characteristics |
Application Areas |
Model advantages |
|
SCN1A knockout |
Gene knockout |
Mice |
Dravet syndrome, spontaneous seizures |
Genetic epilepsy mechanisms and gene therapy |
Highly simulates human Dravet syndrome; suitable for studying sodium channel-related pathologies |
|
CHRNA4 knock-in |
Point mutation knock-in |
Mice |
Nocturnal frontal lobe epilepsy |
Neural receptor targeted drug development |
Accurate simulation of autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) |
|
KCNQ2 mutations |
Conditional dominant negative |
Transgenic mice |
Benign familial neonatal epilepsy |
Study on the relationship between potassium channel function and epilepsy |
Simulate BFNC, suitable for neonatal epilepsy mechanism and drug screening |
|
LGI1 knockout |
Gene knockout |
Mice |
Idiopathic temporal lobe epilepsy |
Autoimmune epilepsy research |
Simulates genetic epilepsy with auditory features; can be used to explore immunomodulatory treatment |
Accurate Modeling ：Provides a full-cycle model from acute onset to chronic spontaneous epilepsy, supporting customized induction plans.
Data support ：Supporting electroencephalogram (EEG/Video-EEG), behavioral analysis and histopathology testing services.
Compliance assurance : Comply with AAALAC international animal welfare standards and provide ethical approval assistance services.
Research Advisory Team ：Recommend the best model solution based on your experimental goals (such as drug targets, pathological stages, species requirements).
Technical Support : Full-process service from model building to data analysis to help you complete your research efficiently!
Note : For specific model parameters, cycles and quotations, please consult our dedicated customer service.
Mobile/WeChat :18701856899
Consultation Email :18701856899@163.com
