Structure and function : Bradykinin is an active peptide composed of 9 amino acids, which is generated by kallikrein acting on kininogen. It mediates a variety of physiological effects by binding to bradykinin receptors (B1R and B2R): 1. Vasodilation and permeability ：Activates endothelial cells to release nitric oxide (NO) and prostacyclin, leading to a decrease in blood pressure and edema at the site of inflammation. 2. Pain sensitivity ：Stimulate nerve endings to release substance P and enhance pain signal transmission. 3. Inflammation regulation ：Promote mast cells to release histamine, exacerbating inflammatory response.
Research Applications : • In vitro studies ：Analysis of endothelial cell function and receptor signaling pathways (such as Ca²⁺ influx detection). • In vivo studies ：Animal models of inflammation/pain, hypertension or cardiovascular disease mechanism research.
Complete sequence
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg
Simplify sequence
RPPGFSPFR
Molecular formula
C₅₀H₇₃N₁₅O₁₁
Molecular weight
1060.21
Product Attributes
purity
>95%
form
Lyophilized powder
Storage conditions
Store in a dry place at -20°C
Instructions
After receiving the product, please store it in accordance with the conditions recommended in the instructions. Unless otherwise specified, the relevant products are all lyophilized powders. Since trace amounts of polypeptides are deposited in the tube during the lyophilization process, forming a very thin or invisible polypeptide layer, Before capping the tube, we recommend centrifuging at about 8,000-12,000 g for 10-30 seconds to allow the peptides attached to the tube cap or tube wall to accumulate at the bottom of the tube.
Please refer to relevant literature for the specific optimal working concentration, or explore and optimize through experiments based on the purpose of the experiment and specific cells and animals.
Our company can provide customized synthesis of high-polypeptide, virtual screening of compounds, Animal disease model construction, Drug safety verification, Application technology support for gene editing animals, etc. For specific application consultation, please contact the sales department.
We look forward to your inquiries:
Sales Department 1: Manager Han Mobile phone: 18701856899
