Cre tool mouse

Strain name

Strain Background

Cre type/promoter

Target cells/tissues

Application Scenario

B6.Cg-Tg(CMV-cre)1Cgn/J

C57BL/6

Cre driven by the constitutive CMV promoter

Widely expressed throughout the body

Basic research (needs to be crossed with floxed mice to achieve systemic knockout), but may result in missed cuts or embryonic lethality.

B6.Cg-Tg(Sox2-cre)1Amc/J

C57BL/6

Sox2 (Epithelial Stem Cell Cre)

Epithelial stem cells such as skin, lung, and intestine

Study tissue regeneration, epithelial carcinogenesis or stem cell function.

​B6.Cg-Tg(Alb-cre)21Mgn/J

C57BL/6

Alb (albumin promoter drives Cre)

Hepatocytes

Liver-specific genetic manipulation (e.g. liver cancer models, metabolic diseases).

​B6;129S-Gt(ROSA)26Sortm1(cre/ERT2)Tmj/J

C57BL/6 × 129S

Insertion of tamoxifen-inducible Cre-ERT2 at the ROSA26 locus

Systemically controllable (requires tamoxifen induction)

Temporally and spatially specific gene knockout in adult animals avoids developmental lethal effects.

B6.Cg-Tg(Nes-cre)1Kln/J

C57BL/6

Nestin (Neural Stem Cell/Progenitor Cell Cre)

Central nervous system (neurons, glial cells)

Neurodevelopmental, glioma, or neurodegenerative disease research.

​B6.Cg-Tg(Myh6-cre/ERT2)1Jmk/J

C57BL/6

Myh6 (α-myosin heavy chain, inducible Cre)

Cardiomyocytes

Cardiac disease models (e.g., post-myocardial infarction repair, myocardial fibrosis).

​B6.129S4-Cd19tm1(cre)Cgn/J

C57BL/6 × 129S4

CD19 (B cell-specific Cre)

B lymphocytes

Research on immune response, B-cell lymphoma or autoantibody related diseases.

​B6.Cg-Tg(Tek-cre)1Ywa/J

C57BL/6

Tek (Tie2, Endothelial Cre)

Endothelial cells

Angiogenesis, tumor vascularization or atherosclerosis research.

B6.Cg-Tg(Lyz2-cre)1Ifo/J

C57BL/6

Lyz2 (lysozyme, myeloid cell Cre)

Macrophages, neutrophils

Research on infection immunity and tumor-associated macrophage (TAM) function.

​B6.Cg-Tg(UBC-cre/ERT2)1Ejb/J

C57BL/6

Ubiquitin C promoter drives tamoxifen-inducible Cre

Systemic induction (requires tamoxifen)

Study the function of genes in adulthood (avoiding interference during development).