Terlipressin

Basic Description

​​​​ Structure and function ​:
Terlipressin is a synthetic dodecapeptide that is a prodrug of arginine vasopressin (AVP) and activates vasopressin. ​V1 receptors​​ How it works:
1. ​​Splanchnic vasoconstriction​ ​：Selectively constrict visceral blood vessels, reduce portal vein pressure, and control esophageal varicose vein bleeding.
2. ​​Improved kidney function​ ​：Used for hepatorenal syndrome (HRS) to improve renal function by increasing renal blood perfusion.

​ ​Application Areas​ ​:
• ​Clinical treatment ​：Cirrhosis, portal hypertension, bleeding, hepatorenal syndrome.
• ​​Research ​：Portal hypertension model, vascular receptor signaling mechanism.

​ ​Three-letter sequence​

Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH₂

​ ​Single letter sequence​

GGGCFYQNCPKG-NH₂

Molecular formula

C₅₂H₇₄N₁₆O₁₅S₂

Molecular weight

1227.4

purity

>98%

form

Lyophilized powder

Storage conditions

Store at -20°C/-80°C away from light