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Deslorelin

Deslorelin​​ is a potent synthetic GnRH (gonadotropin-releasing hormone) analog with dual applications in veterinary medicine and human reproductive endocrinology. This compound exerts its therapeutic effects through sustained pituitary stimulation that ultimately leads to suppression of gonadotropin secretion, thereby modulating sex hormone levels.

In veterinary reproduction management, Deslorelin is routinely employed for ovulation induction and gonadal function suppression. In human clinical practice, it serves as an effective treatment for hormone-dependent conditions such as prostate cancer. Characterized by rapid onset of action and prolonged duration, Deslorelin has become an indispensable pharmacological tool for reproductive endocrine regulation.

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Product Overview

Basic Description

Structure and Function:​
· ​​Deslorelin​​ is a ​​synthetic decapeptide​​ belonging to the class of ​​gonadotropin-releasing hormone (GnRH) agonists​​.
· Its primary mechanism involves ​​activating GnRH receptors​​, thereby stimulating the secretion of ​​luteinizing hormone (LH)​​ and ​​follicle-stimulating hormone (FSH)​​.
· During the initial phase, it transiently increases LH and FSH secretion, followed by ​​receptor downregulation​​ that ultimately suppresses ovarian or testicular function through reduced gonadotropin levels.

​In Vitro and In Vivo Studies:​
· ​​In vitro studies​​ demonstrate Deslorelin's potent ​​activation of GnRH receptors​​.
· ​​In vivo studies​​ confirm its efficacy in ​​suppressing ovarian/testicular function​​ and ​​reducing sex hormone levels​​.
· ​​Clinically​​, Deslorelin is used to treat ​​prostate cancer​​, ​​endometriosis​​, and ​​central precocious puberty​​.

Complete sequence

Pyr-His-Trp-Ser-Tyr-DTrp-Leu-Arg-Pro-NHEt

Simplify sequence

QHWSYwLPR-NHEt

CAS

57773-65-6

Molecular formula

C64H83N17O12

Molecular weight

1282.48 g/mol

Product Attributes

purity

>98%

form

Lyophilized powder

Storage conditions

-20°C/-80°C


Instructions
  • After receiving the product, please store it in accordance with the conditions recommended in the instructions. Unless otherwise specified, the relevant products are all lyophilized powders. Since trace amounts of polypeptides are deposited in the tube during the lyophilization process, forming a very thin or invisible polypeptide layer,
    Before capping the tube, we recommend centrifuging at about 8,000-12,000 g for 10-30 seconds to allow the peptides attached to the tube cap or tube wall to accumulate at the bottom of the tube.
  • Please refer to relevant literature for the specific optimal working concentration, or explore and optimize through experiments based on the purpose of the experiment and specific cells and animals.
Our company can provide customized synthesis of high-polypeptide, virtual screening of compounds, Animal disease model construction,
Drug safety verification,
Application technology support for gene editing animals, etc.
For specific application consultation, please contact the sales department.

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