Epifibatide

Basic Description

​ ​Structure and function​ ​:
Epitifibatide is a synthetic cyclic heptapeptide with high affinity for ​KGD (Lys-Gly-Asp)​​ sequence, by competitively binding to the GP IIb/IIIa receptor on the platelet surface, blocking fibrinogen-mediated platelet aggregation and inhibiting thrombosis.

​ ​Application Areas​ ​:
• ​Clinical treatment ​:
- Acute Coronary Syndrome (ACS)
- Antithrombotic therapy during percutaneous coronary intervention (PCI).
• ​​Research ​：Platelet activation mechanism, thrombotic disease model.

​ ​Three-letter sequence​

N6-(Mercaptopropionyl)-Har-Gly-Asp-Trp-Pro-Cys-NH₂ (Har = homoarginine; Cys forms a disulfide bond ring with mercaptopropionyl)

​ ​Single letter sequence​

[Mpr]-HGDWPC-NH₂ (ring structure: Cys6 forms a disulfide bond with the mercaptopropionyl group)

Molecular formula

C₃₅H₄₉N₁₁O₉S₂

Molecular weight

832.0

purity

>98%

form

Lyophilized powder

Storage conditions

Store at -20°C/-80°C away from light