Icatibant

Name: Icatibant
Brand: Shanghai Kangna Biotechnology Co., Ltd. official website
Availability: InStock
Rating: 5 (1 reviews)

Icatibant is a synthetic decapeptide that is a bradykinin B2 receptor antagonist. Its main effect is to reduce inflammation and increased vascular permeability by blocking bradykinin B2 receptors. Icatibant is used to treat acute attacks of hereditary angioedema (HAE).

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Product Overview

Basic Description	Structure and function: Icatibant is a synthetic decapeptide that is a bradykinin B2 receptor antagonist. Its main effect is to reduce inflammation and increased vascular permeability by blocking bradykinin B2 receptors. Icatibant is used to treat acute attacks of hereditary angioedema (HAE). In vitro and in vivo studies: In in vitro experiments, icatibant can significantly block bradykinin B2 receptors. In vivo, icatibant was able to effectively reduce inflammation and edema.
Three-letter sequence	D-Arg-Arg-Pro-Hyp-Gly-Ile-Ser-D-Cha-Oic-Arg
Single letter sequence	DRRPHGISDCOR
CAS Number	130308-48-4
Molecular formula	C55H90N20O14
Molecular weight	1159.37 g/mol

Product Attributes

purity	>98%
form	Lyophilized powder
Storage conditions	Store at -20°C/-80°C away from light

Instructions

After receiving the product, please store it in accordance with the conditions recommended in the instructions. Unless otherwise specified, the relevant products are all lyophilized powders. Since trace amounts of polypeptides are deposited in the tube during the lyophilization process, forming a very thin or invisible polypeptide layer,
Before capping the tube, we recommend centrifuging at about 8,000-12,000 g for 10-30 seconds to allow the peptides attached to the tube cap or tube wall to accumulate at the bottom of the tube.

Please refer to relevant literature for the specific optimal working concentration, or explore and optimize through experiments based on the purpose of the experiment and specific cells and animals.

Our company can provide customized synthesis of high-polypeptide, virtual screening of compounds, Animal disease model construction,
Drug safety verification, Application technology support for gene editing animals, etc.
For specific application consultation, please contact the sales department.

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Icatibant

Product Details

Technical Support