Nesiritide

Basic Description

Structure and function:
Nesiritide is a synthetic peptide consisting of 32 amino acids and is an analog of human brain natriuretic peptide (BNP).
Its main effect is to increase intracellular cGMP levels by activating granular guanylate cyclase, thereby dilating blood vessels, lowering blood pressure and reducing cardiac workload.
In vitro and in vivo studies:
In in vitro experiments, nesiritide can significantly increase the production of cGMP.
In in vivo experiments, nesiritide can effectively reduce blood pressure and cardiac workload in patients with heart failure.
In clinical applications, nesiritide is used to treat acute decompensated heart failure.

​ ​Three-letter sequence​

​ ​Single letter sequence​

CAS Number

Molecular formula

Molecular weight

purity

>98%

form

Lyophilized powder

Storage conditions

Store at -20°C/-80°C away from light