μ-Conotoxin μ-Conotoxin

Basic Description

​​​ ​Structure and function​ ​:
μ-Conotoxin is a class of Conus geographus ) short peptide toxins (usually containing 16-22 amino acids and 3 pairs of disulfide bonds), ​Selectively inhibits specific subtypes of voltage-gated sodium channels (VGSCs) ​(such as muscle-type Nav1.4 or neuronal-type Nav1.2), blocking the conduction of action potentials.

​ ​Research Applications​ ​:
• ​Electrophysiology ​：Study the functions and pharmacological properties of sodium channel subtypes.
• ​Neuroscience ​：Pain signal transmission mechanism and regulation of neural excitability.
• ​​Drug Development​ ​：Screening of lead compounds for sodium channel-targeted analgesics or anti-epileptic drugs.

​ ​Three-letter sequence​

Arg-Cys-Cys-Pro-Asp-Gly-Cys-Ser-Ala-Ser-Arg-Cys-Cys-Tyr-Gln-Lys-Cys-Arg (Cys2-Cys8, Cys3-Cys16, Cys7-Cys17 form disulfide bonds)

​ ​Single letter sequence​

RCCPDGCSASRCCYQKCR (disulfide bond closed ring)

Molecular formula

C₁₀₃H₁₆₅N₃₁O₃₁S₇

Molecular weight

2607.1

purity

>98%

form

Lyophilized powder

Storage conditions

Store at -20°C/-80°C away from light