TYR-D-ALA-GLY-PHE-LEU (D-ALA2)-Leupeptin

Basic Description

Structure and function ​:
This pentapeptide is a synthetic analog of Leu-Enkephalin with the sequence: ​Tyr-D-Ala-Gly-Phe-Leu​ ​, which works through the following features:
1. ​​Receptor selectivity​ ​：Specific binding ​Delta-opioid receptor (DOR)​ ​, has a lower affinity for μ-receptors, reducing side effects such as respiratory depression.
2. ​​Stability enhancements​ ​：D-Ala² substitution improves peptidase resistance and prolongs half-life in vivo.
3. ​​Analgesia research ​：Used for the study of neuropathic pain models and opioid receptor signaling mechanisms.

​ ​Application Areas​ ​:
• ​​Basic research​ ​：Opioid receptor functional analysis, pain signaling pathway model.
• ​​Drug Development​ ​：Screening of lead compounds for new analgesics.

​ ​Three-letter sequence​

Tyr-D-Ala-Gly-Phe-Leu

​ ​Single letter sequence​

Y-a

CAS Number

64963-01-5

Molecular formula

C₃₁H₄₂N₆O₈

Molecular weight

650.71

purity

>98%

form

Lyophilized powder

Storage conditions

Store at -20°C/-80°C away from light