β-Amyloid (1-42), human TFA

Basic Description

Structure and function ​:
β-Amyloid (1-42) is a neurotoxic peptide composed of 42 amino acids, which is generated by cleavage of amyloid precursor protein (APP) by β- and γ-secretases. It is the core component of amyloid plaques in Alzheimer's disease (AD). Its aggregation can form oligomers, fibrils and insoluble plaques, leading to neuronal damage and synaptic dysfunction.

​ ​Research Applications​ ​:
• ​In vitro studies ​：Induce neuronal cell apoptosis, activate microglial inflammatory response, and study the mechanism of amyloid protein aggregation (such as thioflavin T staining, electron microscopy observation).
• ​In vivo studies ​：Used for pathological verification or therapeutic drug evaluation of transgenic AD mouse models (such as APP/PS1 mice).

​ Features ​:
- Trifluoroacetate (TFA) form for improved solubility and stability.
- Can spontaneously aggregate to form β-folded structures, and dissolution and storage conditions must be strictly controlled to maintain experimental consistency.

Complete sequence

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala -Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala

Simplify sequence

DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

Molecular formula

C₂₀₃H₃₁₁N₅₅O₅₉S (TFA salt)

Molecular weight

4514.43

purity

>95%

form

Lyophilized powder (TFA salt)

Storage conditions

Store at -80°C away from light and avoid repeated freezing and thawing