Semaglutide Impurities, des-20-1-AEEA,20-2-AEEA-SMT

Name: Semaglutide Impurities, des-20-1-AEEA,20-2-AEEA-SMT
Brand: Shanghai Kangna Biotechnology Co., Ltd. official website
Availability: InStock
Rating: 5 (1 reviews)

The semaglutide impurity des-20-1-AEEA,20-2-AEEA-SMT is a structural defect that may be produced during the synthesis or storage of semaglutide. Semaglutide is a long-acting GLP-1 receptor agonist widely used in the treatment of type 2 diabetes and obesity. The impurity is characterized by the simultaneous absence of the 1-AEEA and 2-AEEA modification groups at the 20th position, which may affect the stability, potency or pharmacokinetic properties of the drug. In drug quality control, the monitoring of this type of impurity is crucial to ensure the safety and efficacy of the drug.

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Product Overview

Basic Description	Structure and function: 1. des-20-1-AEEA,20-2-AEEA-SMT is an impurity of semaglutide that lacks the two AEEA-modified moieties at the 20th lysine position. 2. It is a GLP-1 receptor agonist that regulates blood glucose levels by mimicking intestinal secretion of glucagon-like peptide-1 (GLP-1). 3. Due to the lack of two modified moieties, its biological activity and pharmacokinetic properties may differ from those of semaglutide. In vitro and in vivo studies: 1. In vitro studies have shown that des-20-1-AEEA,20-2-AEEA-SMT can still bind to and activate the GLP-1 receptor, but its affinity and potency may be reduced. 2. In vivo studies have shown that the hypoglycemic effect of this impurity in animal models is weaker than that of semaglutide, and its half-life may be shorter. 3. Preclinical studies have shown that des-20-1-AEEA,20-2-AEEA-SMT may cause adverse reactions or reduced efficacy in some cases.
Three-letter sequence	H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Lys(γ-Glu-Octadecanedioic Acid)-Ile-Trp-Leu-Val-Lys-Gly-Asp-Val-Arg-Arg-Arg-Arg-Arg-Arg-Gly-CONH2
Single letter sequence	HHAEGTFTSDVSSYLEGQAK(γ-Glu-Octadecanedioic Acid)ITWLVLVKGDVRRAARRRRG-NH2
Molecular formula	C184H288N48O56S
Molecular weight	4034.16 g/mol

Product Attributes

purity	>98%
form	Lyophilized powder
Storage conditions	Store at -20°C/-80°C away from light

Instructions

Please store the product immediately according to the recommended conditions in the instructions upon receipt. Unless otherwise specified, all products are freeze-dried powders. Since trace amounts of peptides are deposited in the tube during the freeze-drying process, forming a very thin or invisible peptide layer, we recommend centrifuging at about 8,000-12,000g for 10-30 seconds in a centrifuge before opening the tube cap, so that the peptides attached to the tube cap or tube wall are aggregated at the bottom of the tube.

Please refer to relevant literature for the specific optimal working concentration, or explore and optimize through experiments based on the purpose of the experiment and specific cells and animals.

Our company can provide customized synthesis of high-polypeptide, virtual screening of compounds, Animal disease model construction,
Drug safety verification, Application technology support for gene editing animals, etc.
For specific application consultation, please contact the sales department.

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Semaglutide Impurities, des-20-1-AEEA,20-2-AEEA-SMT

Product Details

Technical Support