Semaglutide Impurities, des-20-Lys(AEEA-AEEA-γ-Glu-Octadecanedioic Acid)-SMT

Basic Description

Structure and function:
1. des-20-Lys(AEEA-AEEA-γ-Glu-Octadecanedioic Acid)-SMT is an impurity of semaglutide, lacking lysine 20 and its modified portion (AEEA-AEEA-γ-Glu-octadecanediolic acid).
2. It is a GLP-1 receptor agonist that regulates blood glucose levels by mimicking intestinal secretion of glucagon-like peptide-1 (GLP-1).
3. Due to the lack of an amino acid residue and its modified portion, its biological activity and pharmacokinetic properties may be different from those of semaglutide.
In vitro and in vivo studies:
1. In vitro studies have shown that des-20-Lys(AEEA-AEEA-γ-Glu-Octadecanedioic Acid)-SMT is still able to bind to and activate the GLP-1 receptor, but its affinity and potency may be reduced.
2. In vivo studies have shown that the hypoglycemic effect of this impurity in animal models is weaker than that of semaglutide, and its half-life may be shorter.
3. Preclinical studies have shown that des-20-Lys(AEEA-AEEA-γ-Glu-Octadecanedioic Acid)-SMT may cause adverse reactions or reduced efficacy in some cases.

​ ​Three-letter sequence​

​ ​Single letter sequence​

Molecular formula

Molecular weight

purity

>98%

form

Lyophilized powder

Storage conditions

Store at -20°C/-80°C away from light