Semaglutide Impurities des-5-Thr-SMT

Basic Description

Structure and function:
1. des-5-Thr-SMT is an impurity of semaglutide that lacks the threonine residue at position 5.
2. This deficiency may affect its GLP-1 receptor binding ability and biological activity.
3. Due to the lack of a key amino acid residue, its overall structure and function may be affected.
In vitro and in vivo studies:
1. In in vitro experiments, the GLP-1 receptor activation ability of des-5-Thr-SMT was lower than that of semaglutide.
2. In vivo studies have shown that this impurity also reduces the effect of blood sugar control.
3. Studies in animal models have shown that this impurity may lead to decreased drug efficacy, but the specific mechanism needs further study.
4. Preclinical studies suggest that the safety of des-5-Thr-SMT needs further evaluation.

​ ​Three-letter sequence​

​ ​Single letter sequence​

Molecular formula

Molecular weight

purity

>98%

form

Lyophilized powder

Storage conditions

Store at -20°C/-80°C away from light